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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
09:14

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Published on: February 16, 2018

A more comprehensive and highly practical solution to enantioselective aldehyde crotylation.

Hyunwoo Kim1, Stephen Ho, James L Leighton

  • 1Department of Chemistry, Columbia University, New York, New York 10027, USA.

Journal of the American Chemical Society
|April 14, 2011
PubMed
Summary

This study introduces a highly effective scandium triflate (Sc(OTf)(3)) catalyzed method for enantioselective crotylation of aldehydes. This advanced technique significantly broadens the substrate scope, offering a more practical approach to this important chemical transformation.

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