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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
Published on: September 20, 2019
The centrosome: a target for cancer therapy
Marco Mazzorana1, Guillermo Montoya, Gulnahar B Mortuza
1Macromolecular Crystallography Group, Structural Biology and Biocomputing Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernandez Almagro 3, 28029 Madrid, Spain.
Current Cancer Drug Targets
|April 14, 2011
Summary
The centrosome is crucial for cell division and organization. Its proteins are key targets for developing new anti-cancer therapies to combat tumor formation.
Area of Science:
- Cell Biology
- Molecular Biology
- Cancer Research
Background:
- The centrosome is a vital organelle regulating cell cycle progression, cell polarity, and microtubule organization during interphase and mitosis.
- During cell division, the centrosome undergoes significant structural and functional changes to form the bipolar mitotic spindle, ensuring accurate chromosome segregation.
- Numerous signaling proteins and macromolecular complexes at the centrosome, including protein kinases like Aurora A, Polo, and Neks, precisely modulate cell division events.
Purpose of the Study:
- To review essential centrosomal proteins and their therapeutic potential in cancer treatment.
- To summarize current intervention strategies targeting the centrosome.
- To report the current status of anti-cancer drug development focused on the centrosome.
Main Methods:
- Literature review of centrosomal proteins and their functions.
- Analysis of signaling pathways and protein interactions involved in centrosome regulation.
- Survey of existing and emerging anti-cancer therapeutic strategies targeting the centrosome.
Main Results:
- Centrosomal proteins, particularly kinases, play critical roles in regulating centrosome duplication, maturation, and division.
- Dysregulation of centrosome structure and signaling is strongly linked to aberrant cell proliferation and tumorigenesis.
- Specific centrosomal proteins and pathways represent promising targets for novel anti-cancer drug development.
Conclusions:
- The centrosome's central role in cell division and its frequent dysregulation in cancer make it an attractive target for therapeutic intervention.
- Targeting centrosomal proteins offers a promising avenue for developing innovative anti-cancer therapies.
- Further research into centrosomal protein functions and interactions can accelerate the development of effective anti-cancer drugs.
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To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
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