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Related Concept Videos

Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Gustation01:43

Gustation

Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Related Experiment Video

Updated: Jun 2, 2026

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
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Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx

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The two faces of capsaicin.

Ann M Bode1, Zigang Dong

  • 1The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.

Cancer Research
|April 14, 2011
PubMed
Summary

Capsaicin, found in chili peppers, may increase skin cancer risk when applied topically with tumor promoters like sunlight. Further research is needed on capsaicin

Area of Science:

  • Toxicology
  • Dermatology
  • Pharmacology

Background:

  • Capsaicin, the active compound in chili peppers, has a controversial safety profile regarding consumption and topical use.
  • Research is conflicting on whether capsaicin acts as a carcinogen or a cancer preventive agent.
  • Capsaicin's unique desensitization property is utilized in pain relief creams, though effectiveness and side effects are debated.

Purpose of the Study:

  • To investigate the effects of chronic topical capsaicin application on skin carcinogenesis in a mouse model.
  • To assess potential risks associated with capsaicin use, particularly in conjunction with tumor promoters.

Main Methods:

  • Mice were subjected to chronic, long-term topical application of capsaicin.
  • Mice were also treated with a known tumor promoter to evaluate combined effects on skin carcinogenesis.

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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

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Last Updated: Jun 2, 2026

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
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Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

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Published on: February 13, 2018

Main Results:

  • Chronic topical capsaicin application significantly increased skin carcinogenesis in mice exposed to a tumor promoter.
  • These findings suggest a potential interaction between capsaicin and environmental carcinogens.

Conclusions:

  • Caution is advised when using topical capsaicin products, especially in individuals exposed to tumor promoters such as sunlight.
  • The study highlights the need for further investigation into the carcinogenic potential of capsaicin under specific conditions.