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The effect of aging on the D1 dopamine receptors in human frontal cortex
J de Keyser1, J P De Backer, G Vauquelin
1Department of Neurology, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
Brain Research
|October 1, 1990
Abstract:
Dopaminergic pathways to the cerebral cortex may be involved in cognitive function. We examined the effect of aging on the D1 dopamine receptors, and their high-agonist affinity (RH) sites, in postmortem human frontal cortex (n = 32; age range, 19-88 years). With aging, there was a significant decrease in the densities of the D1 dopamine receptors, and their RH sites, in human frontal cortex. The age-related reduction of cortical dopaminergic neurotransmission might contribute to the decline in cognitive abilities of elderly persons.