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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
Immunopathogenesis of inflammatory bowel disease
Julien Matricon1, Nicolas Barnich, Denis Ardid
1Clermont Université; Université d'Auvergne; Pharmacologie Fondamentale et Clinique de la Douleur; Laboratoire de Pharmacologie Médicale; Inserm U 766; Clermont-Ferrand, France.
Self/Nonself
|April 14, 2011
Summary
Inflammatory bowel disease (IBD) involves genetic and environmental factors. Gut bacteria and immune responses are key to IBD
Area of Science:
- Gastroenterology and Immunology
Background:
- Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory condition.
- Genetic and environmental factors, including sanitation, are implicated in IBD development.
- Molecular mechanisms underlying IBD pathogenesis were previously unclear.
Purpose of the Study:
- To review current knowledge on intestinal epithelial barrier alterations in IBD.
- To examine the dysfunction of mucosal innate and acquired immune responses in IBD.
- To explore the role of gut microbiota and pathogens in IBD immunobiology.
Main Methods:
- Review of recent scientific literature on IBD.
- Analysis of studies on susceptibility genes related to bacterial detection and immune regulation.
- Examination of data on intestinal epithelial barrier function and mucosal immune responses.
Main Results:
- Susceptibility genes involved in bacterial sensing and immune regulation are crucial.
- Alterations in the intestinal epithelial barrier are observed in IBD.
- Dysfunction in both innate and acquired mucosal immune responses contributes to IBD.
Conclusions:
- Pathogenic intestinal bacteria or infectious agents may initiate and perpetuate gut inflammation in genetically susceptible individuals.
- Disruption of tolerance to commensal microbiota plays a role in IBD.
- IBD pathogenesis involves a complex interplay between host genetics, environmental factors, and the gut microbiome.
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