Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Spinal Cord Injury ll: Pathophysiology

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

Secondary Spinal Cord Injury llI: Pathophysiology

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A systematic review and meta-analysis on the benefits of resistance exercise in patients with fibromyalgia.

Journal of bodywork and movement therapies·2026

Same author

Evaluating and refining the wheelchair mobility activity log (WC-MAL): a comprehensive study of validity and reliability.

Spinal cord·2026

Same author

Laterality-dependent biological effects of manual acupuncture stimulation of the auricular vagus nerve in women with fibromyalgia: a randomized, sham-controlled trial.

Pain medicine (Malden, Mass.)·2026

Same author

Spinal cord independence measure evidence-based recommendation: a systematic review of measurement properties.

Spinal cord·2025

Same author

Transcranial magnetic stimulation combined with mindfulness for pain and disability management in migraine patients: a protocol feasibility study.

MethodsX·2025

Same author

Motor-cognitive analysis of dual task walking in chronic obstructive pulmonary disease patients: An observational study using functional near infrared spectroscopy.

PloS one·2025

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Published on: January 16, 2019

Balance and coordination training after sciatic nerve injury.

Leandro Viçosa Bonetti¹, Arthiese Korb, Sandro Antunes Da Silva

¹Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

|April 14, 2011

Summary

Balance and coordination training significantly improved sciatic nerve regeneration in rats. This approach enhanced muscle recovery and sensorimotor function following injury.

More Related Videos

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Published on: September 16, 2013

Related Experiment Videos

Last Updated: Jun 2, 2026

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Published on: January 16, 2019

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Published on: September 16, 2013

Area of Science:

Neuroscience
Regenerative Medicine
Physical Therapy

Background:

Peripheral nerve injuries pose significant challenges to functional recovery.
Existing therapeutic interventions show variable efficacy in enhancing nerve regeneration.

Purpose of the Study:

To investigate the efficacy of balance and coordination training in promoting functional recovery after sciatic nerve crush injury in rats.
To analyze the impact of this training on nerve histology and soleus muscle atrophy.

Main Methods:

Sciatic nerve crush injury was induced in a rat model.
Animals were subjected to balance and coordination training, motor control training, or remained sedentary.
Sensorimotor function was assessed using standardized tests.
Nerve and soleus muscle histology were analyzed post-intervention.

Main Results:

Balance and coordination training significantly improved performance in sensorimotor tests compared to sedentary and motor control groups.
Nerve histology analysis revealed improved myelin sheath thickness and g-ratio in the balance and coordination group.
Soleus muscle area was significantly larger in the balance and coordination group, indicating prevention of atrophy.

Conclusions:

Balance and coordination training is a promising therapeutic strategy for enhancing sciatic nerve regeneration.
This training modality can effectively revert and/or prevent soleus muscle atrophy.
Improved sensorimotor test performance suggests significant functional recovery following this intervention.