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Published on: November 12, 2021
Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum
Albert W W Van Wyk1, Karina M Zuck, Tawnya C McKee
1Molecular Targets Laboratory, Molecular Discovery Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702-1202, United States.
Abstract:
Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines.
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