Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold

Susanna T S Chan, Roger R Nani, Evan A Schauer

  • 1NMR Structure Elucidation, Process Research and Development, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.

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Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable,...
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