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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Marianins A and B, prenylated phenylpropanoids from Mariannaea camptospora
Takao Fukuda1, Yuri Sudoh, Yuki Tsuchiya
1Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
Abstract:
Marianins A (1) and B (2), two new prenylated phenylpropanoids, were isolated from the culture extract of the fungus Mariannaea camptospora. Structures of marianins were elucidated by interpretation of NMR and other spectroscopic data. 1 is a 5-methylcoumarin bearing two prenyloxy groups, while 2 is an orcinol derivative substituted with a 3,3-dimethyl-4-pentenoyl chain. 2 is possibly derived from 1 through a Claisen rearrangement of the prenyl group, followed by lactone hydrolysis and decarboxylation. These compounds showed weak antibacterial activity against Micrococcus luteus.
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