Related Experiment Video
Updated: Jun 2, 2026

Real-Time cAMP Dynamics in Live Cells Using the Fluorescent cAMP Difference Detector In Situ
Published on: March 22, 2024
Intracellular cAMP signaling by soluble adenylyl cyclase
Martin Tresguerres1, Lonny R Levin, Jochen Buck
1Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
None:
Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is distinct from the more widely studied source of cAMP, the transmembrane adenylyl cyclases (tmACs); its activity is uniquely regulated by bicarbonate anions, and it is distributed throughout the cytoplasm and in cellular organelles. Due to its unique localization and regulation, sAC has various functions in a variety of physiological systems that are distinct from tmACs. In this review, we detail the known functions of sAC, and we reassess commonly held views of cAMP signaling inside cells.
More Related Videos
Related Concept Videos
Intracellular Signaling Cascades
Intracellular Signaling Cascades
cAMP-dependent Protein Kinase Pathways
Intracellular Signaling Affects Focal Adhesions
Some...
Amplifying Signals via Second Messengers
GPCRs Regulate Adenylyl Cylase Activity
Two...

