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Published on: October 6, 2019
Two-dimensional optical feedback control of Euglena confined in closed-type microfluidic channels
Kazunari Ozasa1, Jeesoo Lee, Simon Song
1RIKEN Advanced Science Institute, Hirosawa, Wako, Saitama, Japan. ozasa@riken.jp
Lab on a Chip
|April 15, 2011
Summary
Researchers used 2D optical feedback to precisely control Euglena cell behavior in microfluidic devices. This technique allows dynamic manipulation of cell density and position for biological studies and applications.
Area of Science:
- Microfluidics
- Cell Biology
- Biophysics
Background:
- Euglena cells exhibit phototaxis, a response to light.
- Controlling microbial populations in microfluidic environments is challenging.
Purpose of the Study:
- To demonstrate 2D optical feedback control for Euglena cells in microaquariums.
- To explore applications in cell manipulation and computation.
Main Methods:
- Utilized closed-type microfluidic channels (microaquariums).
- Implemented three distinct 2D optical feedback algorithms.
- Monitored and controlled Euglena cell density and position dynamically.
Main Results:
- Achieved dynamic and flexible control over Euglena cell density and position.
- Concentrated over 70% of Euglena cells into a specified area.
- Demonstrated separation of photo-sensitive and photo-insensitive Euglena cells.
- Successfully implemented Euglena-based neuro-computing with 16 artificial neurons.
Conclusions:
- 2D optical feedback control is a promising tool for studying photoreactive microbes.
- Potential applications include microbe-based particle transport and cell separation.
- This method offers precise, external, and dynamic manipulation of microbial populations.
