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Related Concept Videos

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
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Updated: Jun 2, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
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Published on: May 2, 2025

Support surfaces for pressure ulcer prevention.

Elizabeth McInnes1, Asmara Jammali-Blasi, Sally Em Bell-Syer

  • 1Nursing Research Institute, St Vincent's and Mater Health Sydney ACU, National Centre for Clinical Outcomes Research (NaCCOR), Nursing and Midwifery, Australia, Research Room, Level 5 DeLacy Building, St Vincent's Hospital, Victoria Street, Darlinghurst, New South Wales, Australia, 2010.

The Cochrane Database of Systematic Reviews
|April 15, 2011
PubMed
Summary
This summary is machine-generated.

Higher-specification foam mattresses and medical sheepskins effectively reduce pressure ulcer incidence in at-risk individuals. Alternating-pressure mattresses may be more cost-effective than overlays for preventing these ulcers.

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Area of Science:

  • Wound care and prevention
  • Medical device efficacy
  • Geriatric care

Background:

  • Pressure ulcers (bedsores) are localized skin damage common in the elderly and immobile.
  • These ulcers incur significant financial and human costs.
  • Pressure-relieving support surfaces are crucial for ulcer prevention.

Purpose of the Study:

  • To determine if pressure-relieving support surfaces reduce pressure ulcer incidence compared to standard surfaces.
  • To assess the comparative effectiveness of different pressure-relieving surfaces in ulcer prevention.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs) and quasi-randomised studies.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, and CINAHL up to December 2010.
  • Included studies measuring pressure ulcer incidence; excluded studies reporting only proxy outcomes.

Main Results:

  • Foam alternatives to standard hospital mattresses reduced pressure ulcer incidence (RR 0.40).
  • Medical sheepskins prevented pressure ulcers (RR 0.56).
  • Effectiveness of alternating-pressure vs. constant low-pressure devices remains unclear; alternating-pressure mattresses may be more cost-effective than overlays in the UK.

Conclusions:

  • High-risk individuals should use higher-specification foam mattresses over standard ones.
  • Medical-grade sheepskins decrease pressure ulcer development.
  • Consider pressure relief for high-risk patients in operating theatres, though optimal surface types require further research.