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Related Experiment Video

Updated: Jun 2, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Primary intramedullary histiocytic sarcoma.

Gentian Toshkezi1, Faramarz Edalat, Carl O'Hara

  • 1Department of Neurosurgery, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.

World Neurosurgery
|April 16, 2011
PubMed
Summary
This summary is machine-generated.

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Primary central nervous system lymphoma (PCNSL) is rare. This study reports the first case of spinal cord PCNSL caused by histiocytic sarcoma in a 71-year-old woman presenting with back pain and leg weakness.

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Primary central nervous system lymphoma (PCNSL) is a rare malignancy primarily affecting the brain.
  • PCNSL can involve the spinal cord, though intramedullary spinal cord involvement is exceptionally uncommon.
  • Histiocytic sarcoma is a rare subtype of lymphoma.

Observation:

  • A 71-year-old woman presented with symptoms of back pain and progressive unilateral lower extremity weakness.
  • Imaging and subsequent biopsy revealed an intramedullary spinal cord tumor.
  • Histopathological analysis confirmed the tumor as a primary histiocytic sarcoma.

Findings:

  • The patient was diagnosed with an intramedullary primary histiocytic sarcoma of the spine.
  • This represents the first documented case of an intramedullary PCNSL attributed to histiocytic sarcoma.

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Last Updated: Jun 2, 2026

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  • The tumor's location and specific subtype presented unique diagnostic and therapeutic challenges.

    • Implications:

    • This case expands the known spectrum of PCNSL subtypes and their spinal manifestations.
    • Highlights the importance of considering rare lymphoma subtypes in the differential diagnosis of intramedullary spinal cord lesions.
    • Further research into histiocytic sarcoma of the CNS may inform future treatment strategies and improve patient outcomes.