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Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
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Brainstem auditory evoked responses in opioid dependence.

R Lal1, M Bhatia

  • 1R. LAL, Additional Professor, Department of Psychiatry, AIIMS, New Delhi-110 029.

Indian Journal of Psychiatry
|April 16, 2011
PubMed
Summary
This summary is machine-generated.

Opioid dependence prolongs brainstem auditory evoked responses, impacting auditory processing. This study highlights significant delays in auditory pathway function for opioid-dependent individuals compared to healthy controls.

Keywords:
BAEROpioid dependence

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Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
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Published on: May 10, 2019

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Clinical Neurophysiology

Background:

  • Opioid dependence is a significant public health issue.
  • Auditory pathway function can be affected by substance abuse.
  • Brainstem auditory evoked responses (BAERs) are objective measures of auditory pathway integrity.

Purpose of the Study:

  • To investigate brainstem auditory evoked responses (BAERs) in opioid-dependent individuals.
  • To compare BAERs between opioid-dependent subjects and healthy volunteers.
  • To assess the impact of opioid dependence on auditory pathway neurophysiology.

Main Methods:

  • Brainstem auditory evoked responses (BAERs) were recorded.
  • 19 opioid-dependent subjects and 20 healthy volunteers participated.
  • Analysis focused on absolute and interpeak latencies of specific waves (III, V) and intervals (I-III, III-V, I-V).

Main Results:

  • Significant prolongation of absolute latencies for wave III and wave V was observed in the opioid-dependent group.
  • Interpeak latencies (I-III, III-V, I-V) were also significantly prolonged in opioid-dependent subjects.
  • These findings indicate delayed neural transmission in the auditory brainstem.

Conclusions:

  • Opioid dependence is associated with demonstrable alterations in brainstem auditory evoked responses.
  • Prolonged latencies suggest impaired auditory pathway function in opioid-dependent individuals.
  • Further research is warranted to explore the clinical implications and underlying mechanisms.