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Fluorescent trimethyl-substituted naphthyridine as a ligand for C-C mismatch detection in CCG trinucleotide repeats
Yusuke Sato1, Atsuko Honjo, Daisuke Ishikawa
1Department of Chemistry, Graduate School of Science, Tohoku University, Japan, Sendai 980-8578, Japan.
Chemical Communications (Cambridge, England)
|April 16, 2011
Abstract:
We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C-C mismatch present in the hairpin structures of (CCG)(n) trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.
