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Updated: Jun 2, 2026

Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor
Published on: September 29, 2020
Capnography enhances surveillance of respiratory events during procedural sedation: a meta-analysis
Jonathan B Waugh1, Chad A Epps, Yulia A Khodneva
1Department of Clinical and Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA. waughj@uab.edu
Study Objective:
To determine if capnography, in addition to standard monitoring, identified more respiratory complications than standard monitoring alone.
Design:
Meta-analysis.
Setting:
University medical center.
Measurements:
The electronic databases PubMed, CINAHL, and Cochrane Library (Cochrane Reviews, CENTRAL) were searched for studies published between 1995-2009 reporting adverse respiratory events during procedural sedation and analgesia (PSA) with clearly defined end-tidal carbon dioxide threshold, adult population, clear study design, P-value calculation, similar outcome and predictor variable definitions, and binary independent and dependent variable raw data. Five such studies were evaluated independently. A meta-analysis of these studies was performed.
Main Results:
During PSA, cases of respiratory depression were 17.6 times more likely to be detected if monitored by capnography than cases not monitored by capnography (95% CI, 2.5-122.1; P < 0.004).
Conclusion:
End-tidal carbon dioxide monitoring is an important addition in detecting respiratory depression during PSA.
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