Related Experiment Video
Updated: Jun 2, 2026
08:02
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
[Proxy lymphomatoid contact dermatitis]
V Hospital1, S Amarger, F Franck
1Service de dermatologie, CHU, université Clermont-Ferrand, France. vhospital@chu-clermontferrand.fr
Annales De Dermatologie Et De Venereologie
|April 19, 2011
Summary
This case study shows a rare instance of B-cell infiltration in lymphomatoid contact dermatitis, triggered by indirect allergen exposure. It emphasizes the importance of thorough patient history in diagnosing allergic reactions.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Lymphomatoid contact dermatitis typically involves T-cell infiltration.
- This case presents a variant with predominant B-cell infiltration.
Observation:
- A 32-year-old man presented with persistent, steroid-resistant cutaneous lesions.
- Lesions included an infiltrated patch and eczematous areas.
- Biopsy revealed dense dermal infiltration primarily of B cells.
Findings:
- Patch testing identified paraphenylenediamine (PPD) as the allergen.
- The allergen was traced to the patient's spouse's hair dye.
- Complete remission occurred after allergen withdrawal.
Implications:
- A single allergen can induce diverse lymphoid phenotypes.
- Detailed patient history is crucial in allergology diagnosis.
- Highlights indirect allergen exposure as a cause of contact dermatitis.
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