Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Secretory Phase01:19

Secretory Phase

The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of SCN1A mutations in temporal lobe epilepsy: Genetic insights and clinical implications.

Epileptic disorders : international epilepsy journal with videotape·2026
Same author

Prevalence and predictors of atrial fibrillation detected after stroke or transient ischemic attack: A comprehensive meta-analysis.

International journal of stroke : official journal of the International Stroke Society·2025
Same author

Microbial Multidrug-Resistant Organism (MDRO) Mapping of Intensive Care Unit Infections.

Medicina (Kaunas, Lithuania)·2025
Same author

A Novel Approach to an Under-Recognized Entity: Percutaneous Thrombectomy of IVC Filter Thrombosis Complicated With Pulmonary Emboli Using the INARI FlowTriever Device: A Case Report.

Clinical case reports·2025
Same author

Clinical and Demographic Characteristics of Hospitalized Pediatric Measles Cases; The 2023 Outbreak in Northern Jordan.

Infection and drug resistance·2025
Same author

Obesity and overweight and associated factors among women with infertility undergoing assisted reproductive technology treatment in a low income setting.

Scientific reports·2025
Same journal

Confronting complexities of uterus transplantation: Balancing Innovation, Risk and Access.

Fertility and sterility·2026
Same journal

Fertility Benefits and Parental Leave Policies across Accreditation Council for Graduate Medical Education (ACGME) Programs with Ob/Gyn Residency Programs.

Fertility and sterility·2026
Same journal

Optimizing the therapeutic donor insemination cycle.

Fertility and sterility·2026
Same journal

Hormonal and metabolic effects of the administration of oral low-dose 17-β-estradiol (0.2 mg) in patients with Functional Hypothalamic Amenorrhea (FHA): A Retrospective Pilot Study.

Fertility and sterility·2026
Same journal

Biomarker or Bystander? Considering Triglyceride Glucose-Body Mass Index (TyG-BMI) in Patients with Polyendocrine Metabolic Ovarian Syndrome.

Fertility and sterility·2026
Same journal

The Importance of the Incubator: Perinatal Outcomes following Intravaginal Culture.

Fertility and sterility·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Remote Neuronal Activation Coupled with Automated Blood Sampling to Induce and Measure Circulating Luteinizing Hormone in Mice
08:56

Remote Neuronal Activation Coupled with Automated Blood Sampling to Induce and Measure Circulating Luteinizing Hormone in Mice

Published on: August 25, 2023

Hyperreactio luteinalis in pregnancy.

Christian Amoah1, Ahmed Yassin, Eimear Cockayne

  • 1Department of Obstetrics and Gynaecology, The Royal Oldham Hospital, Oldham, United Kingdom. christian_amoah@yahoo.co.uk

Fertility and Sterility
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Hyperreactio luteinalis, a rare pregnancy complication, presents with ovarian enlargement and virilization. Conservative management led to a successful pregnancy and healthy infant, with symptoms resolving postnatally.

More Related Videos

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

Related Experiment Videos

Last Updated: Jun 2, 2026

Remote Neuronal Activation Coupled with Automated Blood Sampling to Induce and Measure Circulating Luteinizing Hormone in Mice
08:56

Remote Neuronal Activation Coupled with Automated Blood Sampling to Induce and Measure Circulating Luteinizing Hormone in Mice

Published on: August 25, 2023

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

Area of Science:

  • Reproductive Endocrinology
  • Obstetrics and Gynecology

Background:

  • Hyperreactio luteinalis (HL) is a benign condition characterized by the excessive development of lutein cells in the ovaries.
  • It is often associated with conditions of increased human chorionic gonadotropin (hCG), such as pregnancy, particularly multiple gestations or molar pregnancies.

Observation:

  • A 30-year-old primigravida presented with painful, multicystic ovarian enlargement and virilizing features during pregnancy.
  • Sonographic examination revealed the characteristic "spoke wheel" appearance suggestive of HL.
  • Elevated serum androgen levels were noted during investigation.

Findings:

  • The patient underwent conservative, symptomatic management.
  • The pregnancy was successfully carried to term, resulting in the live birth of a female infant without gross abnormalities.
  • Postnatally, the patient's clinical features and ovarian enlargement resolved, returning to pre-pregnancy status.

Implications:

  • This case highlights an uncommon obstetric presentation of hyperreactio luteinalis.
  • Conservative management can be effective, leading to favorable maternal and fetal outcomes.
  • It underscores the importance of recognizing and managing HL symptomatically during pregnancy.