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Human resistin: found in translation from mouse to man
Daniel R Schwartz1, Mitchell A Lazar
1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Trends in Endocrinology and Metabolism: TEM
|April 19, 2011
Summary
Resistin, initially found in fat cells, is linked to insulin resistance. However, human resistin from immune cells may act as an inflammatory biomarker and mediator for diabetes and cardiovascular disease.
Area of Science:
- Biochemistry
- Immunology
- Endocrinology
Background:
- Resistin's discovery linked it to insulin resistance and obesity-related diseases.
- Rodent studies confirm adipocyte-derived resistin's role in insulin resistance.
- Human resistin's function is complex, as it's secreted by macrophages and its epidemiological relevance is descriptive.
Purpose of the Study:
- To review current evidence on human resistin's role in health and disease.
- To explore resistin as a potential biomarker and mediator in diabetes and cardiovascular disease.
Main Methods:
- Review of recent scientific literature.
- Analysis of epidemiological data.
- Examination of immunological and endocrinological studies.
Main Results:
- Human resistin is primarily secreted by macrophages, not adipocytes.
- Growing evidence suggests human resistin functions as an inflammatory biomarker.
- Resistin shows potential as a mediator in the development of diabetes and cardiovascular disease.
Conclusions:
- Human resistin's role differs from its rodent counterpart.
- Resistin is implicated as a key inflammatory factor in metabolic and cardiovascular diseases.
- Further research is warranted to fully elucidate resistin's therapeutic potential.
