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Related Concept Videos

Structure of Blood Vessels01:15

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Anatomy of Blood Vessels01:20

Anatomy of Blood Vessels

The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Overview of Blood Vessels01:14

Overview of Blood Vessels

The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...

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Related Experiment Video

Updated: Jun 2, 2026

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera
07:22

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera

Published on: May 6, 2016

LUMENating blood vessels.

M Luisa Iruela-Arispe1

  • 1Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, CA 90095, USA. arispe@mcdb.ucla.edu

Developmental Cell
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

The formation of a lumen, a crucial step in blood vessel development, relies on the small GTPase Rasip. This protein regulates cytoskeleton dynamics and cell adhesion, essential for lumen emergence in vascular morphogenesis.

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En Face Preparation of Mouse Blood Vessels
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Related Experiment Videos

Last Updated: Jun 2, 2026

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera
07:22

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera

Published on: May 6, 2016

En Face Preparation of Mouse Blood Vessels
10:01

En Face Preparation of Mouse Blood Vessels

Published on: May 19, 2017

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
11:12

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography

Published on: October 3, 2018

Area of Science:

  • Vascular biology and developmental biology, focusing on cell morphogenesis.

Background:

  • Vascular lumen acquisition is a fundamental process in the development of blood vessels.
  • Understanding the molecular mechanisms driving lumen formation is key to addressing vascular diseases.

Discussion:

  • The small GTPase Rasip acts as a critical regulator during vascular morphogenesis.
  • Rasip influences both cytoskeleton dynamics and cell adhesion processes.

Key Insights:

  • Xu et al. (2011) identify Rasip as a key player in the emergence of vascular lumens.
  • The study demonstrates that Rasip's regulation of cytoskeleton and cell adhesion is essential for lumen formation.

Outlook:

  • Further research into Rasip's signaling pathways could reveal novel therapeutic targets for vascular disorders.
  • Investigating Rasip's role in other developmental processes may uncover broader biological functions.