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Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Contact Angle01:13

Contact Angle

When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive force...

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Updated: Jun 2, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

Adhesion models: from single to multiple asperity contacts.

Polina Prokopovich1, Victor Starov

  • 1Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, United Kingdom. p.prokopovich@leeds.ac.uk

Advances in Colloid and Interface Science
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

This review summarizes adhesion models for rough surfaces, focusing on multi-asperity contacts. It examines van der Waals forces, contact mechanics, and meniscus effects, integrating surface topography and environmental factors.

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Last Updated: Jun 2, 2026

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Published on: November 2, 2011

Area of Science:

  • Surface Science
  • Materials Science
  • Tribology

Background:

  • Understanding adhesion between rough surfaces is crucial in many engineering applications.
  • Existing models often simplify surface interactions, neglecting key factors like surface roughness and environmental influences.
  • A comprehensive review of current adhesion models is needed to address these limitations.

Purpose of the Study:

  • To review and synthesize current adhesion models for real rough surfaces.
  • To focus on multi-asperity contact interactions, including van der Waals and contact mechanics approaches.
  • To discuss the role of meniscus forces and their integration into adhesion models, considering surface geometry and environmental conditions.

Main Methods:

  • Literature review of adhesion models, from single asperity to multi-asperity contacts.
  • Analysis of van der Waals forces and contact mechanics principles in adhesion.
  • Examination of meniscus models and their dependence on surface topography and environmental factors.

Main Results:

  • Adhesion models range from single asperity to complex multi-asperity interactions.
  • Both van der Waals forces and contact mechanics are critical components of adhesion models.
  • Meniscus forces significantly influence adhesion, particularly under varying surface geometry, topography, and environmental conditions.

Conclusions:

  • A comprehensive understanding of multi-asperity adhesion requires integrating contact mechanics, van der Waals forces, and meniscus effects.
  • Surface topography and environmental conditions play a vital role in meniscus-driven adhesion.
  • Further development of integrated models is necessary for accurate prediction of adhesion between real rough surfaces.