Related Experiment Video
Updated: Jun 2, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Fulminant myelopathy following neurogenic proximal weakness associated with human T-cell lymphotropic virus type I
Satoshi Yamashita1, Akihiko Ueda, Tomoo Hirahara
1Department of Neurology, Faculty of Life Sciences, Kumamoto University, Japan. y-stsh@kumamoto-u.ac.jp
Abstract:
We report a patient with human T-cell lymphotropic virus type I (HTLV-I) infection, who presented with proximal extremity neurogenic muscular weakness followed by fulminant myelopathy, but with no upper motor symptoms. The symptoms were inconsistent with the World Health Organization or El Escorial criteria for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or amyotrophic lateral sclerosis (ALS). This case indicates that fulminant myelopathy without upper motor neuronal symptoms may occur long after the onset of HTLV-I-associated neurogenic proximal muscular weakness. Additionally, we report that treatment with high-dose steroid pulse therapy partially improves symptoms of lightning pain and sensory disturbance.
Related Concept Videos
Poliomyelitis
Cytomegalovirus Disease
Encephalitis ll: Pathophysiology
Multiple Sclerosis l: Introduction
Myasthenia Gravis ll: Pathophysiology
Cryptococcal Meningitis

