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Related Experiment Video

Updated: Jun 2, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Wilms tumor--a renal stem cell malignancy?

Naomi Pode-Shakked1, Benjamin Dekel

  • 1Pediatric Stem Cell Research Institute, Edmond & Lili Safra Children's Hospital, Sheba Center for Regenerative Medicine, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Pediatric Nephrology (Berlin, Germany)
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Wilms tumor, a common pediatric kidney cancer, originates from early renal stem/progenitor cells. Research identified tumor cell populations resembling fetal kidney progenitors, suggesting a potential cancer stem cell origin.

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Published on: April 12, 2017

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Last Updated: Jun 2, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

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Published on: February 8, 2020

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Area of Science:

  • Pediatric Oncology
  • Developmental Biology
  • Cancer Stem Cell Research

Background:

  • Wilms tumor (WT) is the most common pediatric kidney cancer, recapitulating fetal kidney development.
  • The precise cellular origin of WT remains elusive, though implicated in early renal progenitor cells.
  • WT serves as a model for differentiation failure in human neoplasia.

Purpose of the Study:

  • To investigate the cellular origin of Wilms tumor.
  • To identify potential cancer stem cells within Wilms tumor.
  • To explore similarities between Wilms tumor cells and normal kidney progenitors.

Main Methods:

  • Analysis of sorted single human tumor cells from Wilms tumor.
  • Application of novel cancer stem cell methodologies.
  • Comparison of molecular marker expression in tumor cells and fetal kidney progenitors.

Main Results:

  • Identification of Wilms tumor cell sub-populations with molecular markers similar to fetal kidney progenitors.
  • These identified cells are likely derivatives of the same lineage as normal kidney stem cells.
  • The findings support the hypothesis of an early renal stem/progenitor cell origin for Wilms tumor.

Conclusions:

  • Wilms tumor may arise from malignant transformation of early renal stem or progenitor cells.
  • Identifying Wilms tumor cancer stem cells offers potential therapeutic targets.
  • Further research could illuminate normal kidney stem cell biology.