Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney

Technique to Target Microinjection to the Developing Xenopus Kidney

Published on: May 3, 2016

Xenopus pronephros development--past, present, and future.

Oliver Wessely¹, Uyen Tran

¹Department of Cell Biology & Anatomy, LSU Health Sciences Center, New Orleans, LA, USA. wesselo@ccf.org

Pediatric Nephrology (Berlin, Germany)

|April 19, 2011

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of APOL1-Associated Pregnancy Complications on Kidney Disease Phenotypes in a HIV-Associated Nephropathy Mouse Model.

Kidney360·2026

Same author

Biocompatible designated Resin-3D-printed polymers exhibit reproductive toxicity prevented by Parylene-C.

bioRxiv : the preprint server for biology·2026

Same author

A new brake on podocyte injury: ATOH8 meets TGF-β.

American journal of physiology. Renal physiology·2026

Same author

Inflammatory Stromal Aging in Ulcerative Colitis and Colitis-Associated Cancer.

bioRxiv : the preprint server for biology·2026

Same author

A single cell atlas of mouse podocytes upon injury identifies kidney zone-dependent responses.

bioRxiv : the preprint server for biology·2026

Same author

SPATIALLY PATTERNED PODOCYTE STATE TRANSITIONS COORDINATE AGING OF THE GLOMERULUS.

bioRxiv : the preprint server for biology·2026

The simple frog pronephros kidney reveals complex developmental mechanisms. Understanding its signaling and gene regulation offers insights into kidney organogenesis in all vertebrates.

Area of Science:

Developmental Biology
Comparative Anatomy

Background:

Kidney development involves complex inductive events from undifferentiated mesenchyme.
While mammalian kidneys are primary models, simpler pronephric kidneys offer experimental advantages.
Evolutionarily conserved aspects of nephron development are crucial for understanding higher vertebrates.

Observation:

This review focuses on pronephros development in Xenopus (frog).
It examines signaling, transcriptional, and post-transcriptional regulation in renal epithelial cell differentiation.
Even simple pronephric kidneys exhibit intricate organogenesis mechanisms.

Findings:

Pronephros development in Xenopus involves complex signaling pathways.
Transcriptional and post-transcriptional regulation are key to renal epithelial cell differentiation.

More Related Videos

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

In Situ Hybridization in Zebrafish Larvae and Juveniles during Mesonephros Development

In Situ Hybridization in Zebrafish Larvae and Juveniles during Mesonephros Development

Published on: August 13, 2021

Related Experiment Videos

Last Updated: Jun 2, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney

Technique to Target Microinjection to the Developing Xenopus Kidney

Published on: May 3, 2016

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

In Situ Hybridization in Zebrafish Larvae and Juveniles during Mesonephros Development

In Situ Hybridization in Zebrafish Larvae and Juveniles during Mesonephros Development

Published on: August 13, 2021

The study highlights the complexity of kidney organogenesis, even in simpler models.

Implications:

Insights from Xenopus pronephros development are applicable to human kidney development.
Further research combining genome-wide and single-gene analyses is needed.
Understanding conserved mechanisms advances regenerative medicine and treatments for kidney diseases.