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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Awareness in children: a secondary analysis of five cohort studies

A J Davidson1, K R Smith, H J Blussé van Oud-Alblas

  • 1Department of Anaesthesia, Royal Children's Hospital, Melbourne, Australia. andrew.davidson@rch.org.au

Anaesthesia
|April 20, 2011
PubMed

Insights

This study identified risk factors for awareness during pediatric anesthesia. Nitrous oxide maintenance and tracheal tube use were independently associated with increased awareness risk in children.

Area of Science:

  • Anesthesiology
  • Pediatric Medicine
  • Clinical Research

Background:

  • Previous cohort studies reported pediatric anesthesia awareness rates between 0.2% and 1.2%.
  • Individual studies lacked sufficient power to identify specific risk factors.

Purpose of the Study:

  • To pool data from multiple cohort studies to identify factors associated with awareness in pediatric anesthesia.
  • To determine independent risk factors for anesthesia awareness in children.

Main Methods:

  • Pooled raw data from five recent cohort studies on pediatric anesthesia.
  • Analyzed 4486 anesthetic cases, identifying 33 instances of awareness.
  • Utilized logistic regression and multivariable regression analysis to identify associated factors.

Main Results:

  • Nitrous oxide maintenance was weakly associated with awareness (unadjusted OR 2.04, adjusted OR 2.4).
  • Tracheal tube use showed stronger evidence of association with awareness (unadjusted OR 2.78, adjusted OR 3.0).
  • Both factors were independently associated with awareness in multivariable analysis.

Conclusions:

  • Nitrous oxide maintenance and the use of a tracheal tube are significant independent risk factors for awareness during pediatric anesthesia.
  • Findings highlight the need for vigilance regarding these factors to minimize awareness events in children.

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