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Correlation between periodontal disease, inflammatory alterations and pre-eclampsia.

G T Politano¹, R Passini, M L Nomura

¹Department of Pediatric Dentistry, Dental School São Leopoldo Mandic, Campinas, São Paulo, Brazil. gabrielp@mpcnet.com.br

Journal of Periodontal Research

|April 20, 2011

Summary

Periodontitis is clinically associated with pre-eclampsia. However, this study did not confirm that systemic inflammation involving cytokines like TNFα and IL-6 mediates this link.

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Area of Science:

Obstetrics and Gynecology
Periodontology
Immunology

Background:

Pre-eclampsia is a serious pregnancy complication.
Periodontal disease is hypothesized to increase pre-eclampsia risk via inflammatory pathways.
Hypertension-related cytokine release in the periodontal environment may link these conditions.

Purpose of the Study:

To evaluate the association between periodontal disease and pre-eclampsia.
To investigate the correlation of these conditions with interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) mRNA expression.

Main Methods:

A case-control study involving 116 pregnant women (58 with pre-eclampsia, 58 controls).
Periodontal evaluation and socio-demographic data collection.
Analysis of IL-6 and TNFα mRNA expression in peripheral blood using real-time PCR.

Main Results:

An association was found between periodontitis and pre-eclampsia (aOR 3.73).
Increased TNFα mRNA expression was observed in women with pre-eclampsia.
No correlation was found between periodontitis and systemic cytokine (IL-6, TNFα) mRNA levels.

Conclusions:

Periodontitis is clinically related to pre-eclampsia.
The study did not confirm a systemic inflammatory mechanism involving TNFα and IL-6 mediating the link between periodontitis and pre-eclampsia.