Related Experiment Video
Updated: Jun 2, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Breastfeeding and the risk for diarrhea morbidity and mortality
Laura M Lamberti1, Christa L Fischer Walker, Adi Noiman
1Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Insights
Exclusive breastfeeding for infants and any breastfeeding for young children significantly reduces diarrhea incidence, mortality, and hospitalizations. These findings support WHO recommendations for breastfeeding as a crucial child survival strategy.
Area of Science:
- Pediatrics
- Public Health
- Epidemiology
Background:
- Suboptimal breastfeeding practices increase diarrhea morbidity and mortality in developing nations.
- Lack of exclusive breastfeeding (0-5 months) and any breastfeeding (6-23 months) are critical risk factors.
Purpose of the Study:
- To quantify the protective effects of varying breastfeeding levels against diarrhea and all-cause mortality.
- To assess protection against diarrhea incidence, prevalence, mortality, and hospitalization.
Main Methods:
- Systematic literature review (1980-2009) on suboptimal breastfeeding and diarrhea outcomes.
- Random effects meta-analyses to determine pooled relative risks by age and outcome.
Main Results:
- Breastfeeding demonstrates significant protective effects against diarrhea and all-cause mortality.
- Exclusive breastfeeding (0-5 months) and any breastfeeding (6-23 months) offer the greatest protection.
- Not breastfeeding increases diarrhea mortality risk by 10.52 (0-5 months) and 2.18 (6-23 months) compared to breastfeeding.
Conclusions:
- Findings strongly support the World Health Organization's exclusive breastfeeding recommendation for the first six months.
- Breastfeeding is vital for preventing diarrhea-related illness and death throughout the first two years of life.
Background:
Lack of exclusive breastfeeding among infants 0-5 months of age and no breastfeeding among children 6-23 months of age are associated with increased diarrhea morbidity and mortality in developing countries. We estimate the protective effects conferred by varying levels of breastfeeding exposure against diarrhea incidence, diarrhea prevalence, diarrhea mortality, all-cause mortality, and hospitalization for diarrhea illness.
Methods:
We systematically reviewed all literature published from 1980 to 2009 assessing levels of suboptimal breastfeeding as a risk factor for selected diarrhea morbidity and mortality outcomes. We conducted random effects meta-analyses to generate pooled relative risks by outcome and age category.
Results:
We found a large body of evidence for the protective effects of breastfeeding against diarrhea incidence, prevalence, hospitalizations, diarrhea mortality, and all-cause mortality. The results of random effects meta-analyses of eighteen included studies indicated varying degrees of protection across levels of breastfeeding exposure with the greatest protection conferred by exclusive breastfeeding among infants 0-5 months of age and by any breastfeeding among infants and young children 6-23 months of age. Specifically, not breastfeeding resulted in an excess risk of diarrhea mortality in comparison to exclusive breastfeeding among infants 0-5 months of age (RR: 10.52) and to any breastfeeding among children aged 6-23 months (RR: 2.18).
Conclusions:
Our findings support the current WHO recommendation for exclusive breastfeeding during the first 6 months of life as a key child survival intervention. Our findings also highlight the importance of breastfeeding to protect against diarrhea-specific morbidity and mortality throughout the first 2 years of life.
Related Concept Videos
Development of Human Microbiota
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Bacterial Gastroenteritis
Development of the Oral Microbiota
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Dysbiosis of the Gut Microbiota

