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Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
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Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
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Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
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CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

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Related Experiment Video

Updated: Jun 2, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
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Substance use in pregnancy.

Suzanne Wong1, Alice Ordean1, Meldon Kahan1

  • 1Toronto ON.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|April 20, 2011
PubMed
Summary

This guideline provides evidence-based recommendations for screening and managing problematic substance use in pregnant women. Early identification and appropriate care improve outcomes for both mothers and newborns, reducing health care costs.

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Area of Science:

  • Obstetrics and Gynecology
  • Addiction Medicine
  • Maternal-Fetal Medicine

Background:

  • Problematic substance use during pregnancy presents significant challenges for healthcare providers.
  • Improving awareness and knowledge is crucial for effective management.
  • Evidence-based recommendations are needed to guide clinical practice.

Purpose of the Study:

  • To enhance healthcare providers' knowledge and comfort in managing pregnant women with substance use disorders.
  • To provide evidence-based recommendations for the screening and management of problematic substance use in pregnancy.
  • To improve maternal and neonatal outcomes and reduce healthcare costs.

Main Methods:

  • Comprehensive literature search of Medline, PubMed, CINAHL, and Cochrane Library from 1950 to December 2009.
  • Inclusion of systematic reviews, RCTs, controlled clinical trials, and observational studies.
  • Quality of evidence rated using the Canadian Task Force on Preventive Health Care criteria.

Main Results:

  • Evidence-based recommendations for screening and management of problematic substance use during pregnancy and lactation.
  • Urine drug screening is the preferred method when testing is clinically indicated.
  • Methadone maintenance treatment is the standard of care for opioid-dependent pregnant women.

Conclusions:

  • All pregnant women should be screened for alcohol, tobacco, and drug use.
  • A flexible, community-resource-supported approach is recommended for care.
  • Smoking cessation counseling is a first-line intervention; nicotine replacement therapy can be considered.