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Related Experiment Video

Updated: Jun 2, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

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High consumption of Ω-3 polyunsaturated fatty acids decrease plasma homocysteine: a meta-analysis of randomized,

Tao Huang¹, Jusheng Zheng, Ying Chen

¹Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.

Nutrition (Burbank, Los Angeles County, Calif.)

|April 20, 2011

Summary

Omega-3 fatty acid supplementation significantly lowers plasma homocysteine (Hcy) levels. This meta-analysis confirms the benefit of omega-3 polyunsaturated fatty acids (PUFAs) in reducing Hcy.

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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

Nutritional Science
Cardiovascular Health
Biochemistry

Background:

High intake of omega-3 polyunsaturated fatty acids (PUFAs) is linked to reduced plasma homocysteine (Hcy).
Previous human intervention studies on omega-3 PUFAs and Hcy levels yielded inconclusive results.
Homocysteine is an amino acid linked to cardiovascular disease risk.

Purpose of the Study:

To systematically evaluate the impact of omega-3 PUFA supplementation on plasma Hcy levels.
To synthesize evidence from randomized, placebo-controlled trials.

Main Methods:

A systematic literature search was conducted across major databases (Medline, EMBASE, Cochrane).
Included were 11 randomized, placebo-controlled trials comparing omega-3 PUFA supplementation to placebo.
Data extraction and quality assessment were performed independently by two investigators.

Main Results:

The meta-analysis included 702 subjects from 11 trials.
Omega-3 PUFA supplementation demonstrated a significant reduction in plasma Hcy levels.
The weighted mean difference in Hcy was -1.59 μmol/L (95% CI: -2.34 to -0.83) compared to placebo.

Conclusions:

This meta-analysis suggests that omega-3 PUFA supplementation effectively decreases plasma Hcy levels.
Further research is needed to elucidate the clinical implications of reduced Hcy due to omega-3 PUFAs.