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Updated: Jun 2, 2026

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
Published on: October 25, 2016
[Research progress in the relationship between TRPV1 and visceral hypersensitivity in functional gastrointestinal
1Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Abstract:
Transient receptor potential vanilloid 1(TRPV1) is a nonselective cation channel with high permeability for Ca(2+). It may play a role in the development and maintenance of visceral pain and hypersensitivity states, which has generated a major interest in the development of specific vanilloid antagonists. In this review, a summary of the contribution of TRPV1 in the development of visceral hypersensitivity in functional dyspepsia and irritable bowel syndrome is presented with the structure, location, and related molecular mechanisms.
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