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Updated: Jun 2, 2026
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
Published on: February 28, 2015
A colorimetric assay method for Co2+ based on thioglycolic acid functionalized hexadecyl trimethyl ammonium bromide
Fuqiang Zhang1, Leyong Zeng, Yingxin Zhang
1Division of Functional Materials and Nano Devices, Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology & Engineering (NIMTE), Chinese Academy of Sciences (CAS), Ningbo, Zhejiang 315201, China.
Abstract:
A simple, rapid and sensitive colorimetric assay method for detection of Co(2+) through thioglycollic acid (TGA) functionalized hexadecyl trimethyl ammonium bromide (CTAB) modified Au NPs has been discovered in our work. TGA functionalized CTAB modified Au NPs can be aggregated quickly in the presence of Co(2+) through a cooperative metal-ligand interaction. Transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDS), and UV-vis spectra were used to characterize the Au NPs aggregation. The presence of Co(2+) is monitored by a colorimetric response of functionalized Au NPs, and had a detection limit of 3.0 × 10(-7) M. Moreover, the selectivity of this method has been investigated by comparing with other metal ions (Hg(2+), Na(+), Cu(2+), Cd(2+), Ba(2+), Pb(2+), Mn(2+), Ni(2+), Zn(2+), Fe(2+) and Fe(3+)).
