Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Allergic Reactions

Allergic Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reframing Eczema: Th2-Skewed Contact Sensitization, Atopy Patch Testing, and Systemic Contact Dermatitis.

Current allergy and asthma reports·2026

Same author

Prevalence of Common Contact Allergens in Topical Diaper Preparations for Infants.

Pediatric dermatology·2025

Same author

Kaposiform Hemangioendothelioma With Features of Congenital Hemangioma Treated With Sirolimus.

Pediatric dermatology·2024

Same author

Assessment of the American Academy of Dermatology diagnostic criteria for pediatric atopic dermatitis and modification into a checkbox form: A cross-sectional study.

Pediatric dermatology·2023

Same author

Immunogenicity of Nickel-Further Explored.

Endocrine, metabolic & immune disorders drug targets·2022

Same author

Localized systemic contact dermatitis: The vulva as a clue to identify allergen ingestion.

International journal of women's dermatology·2022

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Compositae-associated allergic contact dermatitis from bisabolol.

Sharon E Jacob¹, Catalina Matiz, Elise M Herro

¹Division of Pediatric and Adolescent Dermatology, Rady Children’s Hospital, University of California, San Diego, San Diego, CA, USA.

Dermatitis : Contact, Atopic, Occupational, Drug

|April 21, 2011

Summary

Bisabolol, a compound found in some moisturizers, can cause allergic contact dermatitis (ACD) in children with atopic dermatitis (AD). This study highlights bisabolol as a potential trigger for ACD in children experiencing moisturizer intolerance.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Related Experiment Videos

Last Updated: Jun 2, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Area of Science:

Dermatology
Allergology
Pediatrics

Background:

Allergic contact dermatitis (ACD) is frequently associated with Compositae-related chemicals.
Children with atopic dermatitis (AD) are particularly susceptible to ACD.
Moisturizers may serve as an unrecognized source of exposure to ACD-inducing agents.

Purpose of the Study:

To investigate ACD in pediatric patients with recalcitrant atopic dermatitis (AD).
To evaluate the role of Aquaphor Healing Ointment (AHO) intolerance in pediatric ACD cases.
To identify specific ingredients in AHO that may trigger allergic reactions.

Main Methods:

Retrospective chart review of pediatric patients patch-tested for AHO ingredients.
Inclusion of patients with a history of AHO intolerance and those exposed to bisabolol.
Patch testing performed using AHO, its components, and bisabolol.

Main Results:

Seven patients with a history of AHO intolerance were identified, six with AD.
Four out of seven patients exhibited positive patch test reactions to AHO and bisabolol.
Bisabolol, a Compositae derivative, was identified as a causative agent in these cases.

Conclusions:

Bisabolol, a sesquiterpene alcohol, is a potential cause of ACD in children.
Consideration of bisabolol is crucial for children with AD and unexplained moisturizer intolerance.
Identifying specific allergens like bisabolol can guide management of ACD in pediatric AD.