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Updated: Jun 2, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Current clinical applications of cardiac computed tomography
1Medizinische Klinik I, Universitätsklinikum Glessen, Klinikstrasse 33, 39352, Giessen, Germany. Stephan.achenbach@innere.med.uni-giessen.de
Multi-detector row CT angiography offers accurate non-invasive detection of coronary artery disease, proving useful for ruling out significant blockages and avoiding invasive procedures in select patients.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Medical Diagnostics
Background:
- Multi-detector row CT (MDCT) provides high-resolution imaging of cardiac anatomy and function.
- Current primary clinical use is non-invasive coronary angiography via contrast injection.
- Cardiac CT also enables coronary calcium quantification and assessment of cardiac morphology and function.
Purpose of the Study:
- To evaluate the clinical utility of MDCT in cardiac imaging.
- To highlight the role of coronary CT angiography in diagnosing coronary artery disease.
- To discuss other applications of cardiac CT and its indications.
Main Methods:
- Coronary CT angiography (CCTA) using intravenous contrast agent.
- Coronary calcium quantification.
- Analysis of cardiac morphology and function.
Main Results:
- CCTA demonstrates high accuracy and a high negative predictive value for detecting coronary artery stenoses.
- MDCT is clinically valuable for excluding coronary artery disease, particularly in patients with low-to-intermediate risk or equivocal stress tests.
- Cardiac CT is indicated for morphology/function assessment when standard methods like echocardiography or cardiac MRI are insufficient.
Conclusions:
- Coronary CT angiography is a valuable tool for non-invasively assessing coronary artery disease.
- MDCT aids in patient selection to avoid unnecessary invasive coronary angiography.
- Expertise and appropriate patient selection are crucial for effective clinical application of cardiac CT.
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