Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cardiology in older adults].

Zeitschrift fur Gerontologie und Geriatrie·2022
Same author

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

Scientific reports·2021
Same author

Novel ageing-biomarker discovery using data-intensive technologies.

Mechanisms of ageing and development·2015
Same author

Relationship between cardiac tissue glycation and skin autofluorescence in patients with coronary artery disease.

Diabetes & metabolism·2015
Same author

Influence of central nervous system-acting drugs on results of cognitive testing in geriatric inpatients.

Zeitschrift fur Gerontologie und Geriatrie·2014
Same author

[Relevance of personal contextual factors of the ICF for use in practical social medicine and rehabilitation].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2014
Same journal

[Journal Club].

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Effect of anticholinergic burden on cardiac functions in older patients.

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

[Communication in later life under institutional conditions : Professional perspectives on communication of ageing people with profound intellectual and multiple disabilities].

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

[Biofunctional age diagnosis in humans. Potentials and limits].

D Pöthig1, W Gerdes, M Viol

  • 1Europäische Vereinigung für Vitalität und Aktives Altern eVAA e. V., Berlin/ Dependance Leipzig, BIC, Leipzig, Germany.

Zeitschrift Fur Gerontologie Und Geriatrie
|April 21, 2011
PubMed
Summary
This summary is machine-generated.

Accurate age diagnosis methods are crucial but scarce. This review outlines the theoretical and methodological needs for developing reliable age diagnostics, paving the way for future vitality and biofunctional age assessments.

Related Experiment Videos

Last Updated: Jun 2, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Area of Science:

  • Gerontology
  • Biometrics
  • Aging research

Context:

  • Growing global demand for validated age diagnosis procedures.
  • Limited availability of practical and reliable methods for age determination.
  • Current gerontological research highlights the need for robust diagnostic models.

Purpose:

  • To review theoretical and methodological requirements for developing age diagnostic models.
  • To analyze current gerontological research to establish fundamentals for future studies.
  • To lay the groundwork for subsequent publications on vitality and biofunctional age measurement systems.

Summary:

  • This study reviews the essential theoretical and methodological criteria for creating effective age diagnostic models.
  • It analyzes existing gerontological research to identify foundational principles for advancing age determination techniques.
  • The findings provide a basis for future research into systems that measure human vitality and biofunctional aging.

Impact:

  • Addresses the critical need for reliable age diagnostic tools.
  • Informs the development of future age assessment methodologies.
  • Contributes to the advancement of gerontological research and personalized health monitoring.