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Published on: December 14, 2017
LINGO1 gene analysis in Parkinson's disease phenotypes
Oswaldo Lorenzo-Betancor1, Lluís Samaranch, Elena García-Martín
1Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
Summary
LINGO1 gene variants may increase Parkinson's disease (PD) risk, particularly for tremor-dominant PD. This suggests LINGO1 plays a role in PD etiology, especially in tremor development.
Area of Science:
- Genetics
- Neurology
- Molecular Biology
Background:
- Parkinson's disease (PD) and essential tremor (ET) may share underlying causes.
- Previous research linked LINGO1 gene variants to an increased risk of ET.
Purpose of the Study:
- To investigate the hypothesis that LINGO1 gene variants increase susceptibility to Parkinson's disease.
- To explore the association between specific LINGO1 single nucleotide polymorphisms (SNPs) and PD risk.
Main Methods:
- Genotyping of PD patients and healthy controls for LINGO1 SNPs rs9652490 and rs11856808.
- Statistical analysis including odds ratios and recessive genetic models to assess SNP association with PD.
Main Results:
- The rs11856808(T/T) genotype was more frequent in PD patients than controls (OR=1.46, P=0.02).
- A recessive genetic model best explained the influence of rs11856808 on PD risk (P=0.01).
- Higher frequency of rs11856808(T/T) was observed in tremor-dominant PD and classical PD (C-PD) subgroups (P=0.004 for C-PD).
Conclusions:
- LINGO1 variants, specifically rs11856808(T/T), are associated with an increased risk of Parkinson's disease.
- The findings suggest LINGO1 may contribute to the etiology of tremor in PD, particularly non-rigid-akinetic phenotypes.
- This association was observed in the Spanish population, indicating a potential role in tremor pathogenesis.
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