Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 2, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

[Study of the HER2 status. Methodological aspects].

L É Zavalishina, Iu Iu Andreeva, A A Riazantseva

    Arkhiv Patologii
    |April 22, 2011
    PubMed
    Summary

    Accurate human epidermal growth factor receptor 2 (HER2) testing is crucial for breast cancer treatment. This paper outlines the best immunohistochemical methods and interpretation guidelines for reliable HER2 assessment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [HER2 status assessment in carcinomas of various localizations. A multicenter morphological study in the Russian Federation].

    Arkhiv patologii·2026
    Same authorSame journal

    [Assessment methodology of pathomorphological regression of melanoma metastasis in the sentinel lymph node after neoadjuvant/perioperative immunotherapy].

    Arkhiv patologii·2026
    Same author

    [Quality control of immunohistochemical studies in Russia in 2025: achievement and prospects].

    Arkhiv patologii·2026
    Same author

    [Classification of non-small cell lung cancer according to the WHO 2021: from morphology to personalized therapy].

    Arkhiv patologii·2026
    Same author

    [Quality control of immunohistochemical studies: compulsory duty or urgent need?]

    Arkhiv patologii·2025
    Same author

    [Analysis of the work of the Immunohistochemical Quality Control Center of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia in 2023].

    Arkhiv patologii·2024

    Area of Science:

    • Oncology
    • Pathology
    • Molecular Diagnostics

    Context:

    • Accurate human epidermal growth factor receptor 2 (HER2) testing is essential for guiding targeted therapy in breast cancer.
    • Inconsistent testing methodologies can lead to suboptimal patient management.
    • Standardization of HER2 assessment is critical for effective clinical decision-making.

    Purpose:

    • To detail the optimal immunohistochemical (IHC) procedures for HER2 testing in breast cancer.
    • To elucidate the principles for accurate assessment and interpretation of HER2 IHC results.
    • To provide a standardized approach for reliable HER2 status determination.

    Summary:

    • The paper describes the recommended immunohistochemical protocol for HER2 evaluation in breast cancer specimens.
    • It emphasizes key principles for the scoring and interpretation of HER2 staining patterns.
    • Guidance is provided on achieving reproducible and accurate HER2 testing results.

    Impact:

    • Improved accuracy in HER2 testing will enhance the selection of patients eligible for HER2-targeted therapies.
    • Standardized protocols can reduce inter-laboratory variability in HER2 assessment.
    • Consistent and reliable HER2 results support evidence-based treatment decisions, ultimately benefiting breast cancer patients.

    More Related Videos

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
    08:28

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

    Published on: May 9, 2025

    Related Experiment Videos

    Last Updated: Jun 2, 2026

    Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
    11:34

    Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

    Published on: December 5, 2017

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
    08:28

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

    Published on: May 9, 2025