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Updated: Jun 2, 2026

Optimization of Processing of Tiebangchui with Highland Barley Wine Based on the Box-Behnken Design Combined with the Entropy Method
Published on: May 19, 2023
[Optimization of extraction procedure of tongmai granules by orthogonal design with pharmacodynamic index]
Xiaobin Jia1, Yang Huang, Bin Chen
1School of Pharmacy, Jiangsu University, Zhenjiang 212013, China. jxiaobin2005@hotmail.com
Objective:
To optimize the extraction technology for anti-myocardial ischemia active component group in tongmai granules.
Method:
The extracting conditions were optimized by using orthogonal experiment and pharmacodynamic index. Employing puerarin, ferulic acid, tanshinone IIA, and salvianolic acid B as indexes, the effects of ethanol concentration, solvent volume, extraction times and extraction time on the extracting process were investigated.
Result:
The optimum extraction process was adding 8 times amount of 70% alcohol, refluxing and extracting for 3 times, 1.5 h each time.
Conclusion:
This extraction process shows good stability and is available for extracting anti-myocardial ischemia component group in tongmnai granules.
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