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Updated: Jun 2, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
[P-selectin gene -2123 polymorphism in children with Henoch-Sch-nlein purpura]
Jing Li1, Yi-Bing Wang, Hua-Lin Liu
1Department of Internal Medicine, Qingdao Medical Care Center for Women and Children, Qingdao, Shandong 266011, China.
Objective:
To investigate whether P-selectin gene -2123 polymorphism is associated with the pathogenesis of Henoch-Sch-nlein purpura (HSP) in children.
Methods:
Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) is used to identify the distribution of allele and genotype frequencies of P-selectin gene promoter -2123 polymorphism in 86 children with HSP (including 40 cases of purpura nephritis) and 70 healthy controls.
Results:
Compared with the healthy controls, the frequencies of GG genotype and G allele of P-selectin promoter -2123 in children with HSP increased significantly (P<0.05). There were no significant differences in P-selectin promoter -2123 genotype and allele frequencies between the patients with and without nephritis.
Conclusions:
P-selectin gene promoter -2123 polymorphism appears to be associated with the pathogenesis of HSP in children.
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