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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

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[Clinical characteristics of human bocavirus infection in 90 children]

Hua-Jie Yan1, Jun Sheng, Wei Dong

  • 1Department of Pediatrics, Nanxiang Hospital of Jiading District of Shanghai, Shanghai 201802, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|April 22, 2011
PubMed

Insights

Human bocavirus (HBoV) is frequently detected in children with respiratory infections, particularly those with wheezing. HBoV, alongside other viruses like RSV, contributes to wheezing in pediatric respiratory illness.

Area of Science:

  • Virology
  • Pediatric Infectious Diseases

Context:

  • Lower respiratory tract infections (LRTI) are common in children.
  • Viral etiologies of pediatric LRTI are diverse, including human bocavirus (HBoV).
  • Understanding the clinical spectrum of HBoV is crucial for diagnosis and management.

Purpose:

  • To investigate the clinical characteristics of human bocavirus (HBoV) infection in children.
  • To determine the prevalence of HBoV in pediatric lower respiratory tract infections.
  • To compare HBoV with other common respiratory viruses.

Summary:

  • Human bocavirus (HBoV) was detected in 10.7% of 843 children with lower respiratory tract infections.
  • HBoV infection was significantly associated with wheezing (17.0% vs. 9.2%, P<0.01).
  • Common symptoms included coughing, wheezing, and fever; co-infections with other viruses were frequent (50%).

Impact:

  • HBoV is identified as a significant cause of wheezing in children, comparable to RSV.
  • The findings highlight the importance of considering HBoV in the differential diagnosis of pediatric respiratory infections.
  • Co-infections are common, emphasizing the need for comprehensive viral detection.
Abstract

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