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Updated: Jun 2, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Patient factors that influence warfarin dose response
1Legacy Health Anticoagulation Clinics, Portland, OR, USA. pwhite@lhs.org
Journal of Pharmacy Practice
|April 22, 2011
Summary
Optimizing warfarin therapy is complex due to its narrow therapeutic index and variable patient responses. Understanding clinical and genetic factors is crucial for effective anticoagulation and preventing thrombosis.
Area of Science:
- Pharmacology
- Clinical Medicine
- Genetics
Background:
- Warfarin is a primary oral anticoagulant for thrombosis treatment and prevention.
- Its narrow therapeutic index and complex influencing factors complicate dose optimization.
- Individualized dosing requires understanding patient-specific variables.
Purpose of the Study:
- To review clinical factors affecting warfarin pharmacokinetics and pharmacodynamics.
- To explore the role of pharmacogenetics in warfarin therapy optimization.
Main Methods:
- Literature review of clinical factors impacting warfarin.
- Analysis of pharmacogenetic influences on warfarin response.
Main Results:
- Patient age, weight, nutrition, disease states, drug interactions, and diet significantly affect warfarin dose.
- Pharmacogenetic variations (e.g., CYP2C9, VKORC1) are key determinants of warfarin efficacy and safety.
Conclusions:
- Personalized warfarin dosing strategies are essential for safe and effective anticoagulation.
- Integrating clinical and pharmacogenetic data improves warfarin therapy management.
- Further research into optimizing warfarin dosing based on individual patient profiles is warranted.
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