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Updated: Jun 2, 2026

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles
Published on: May 5, 2022
Transport of single cells using an actin bundle-myosin bionanomotor transport system
Hideyo Takatsuki1, Hideyuki Tanaka, Kevin M Rice
1Department of Biological Sciences, Marshall University, Huntington, WV, USA.
Abstract:
The potential of using actin bundles for the transport of liposomes and single cells across myosin-coated surfaces is investigated. Compared to that observed with filamentous actin, the liposome transport using actin bundles was more linear in nature and able to occur over longer distances. Bundles, but not filamentous actin, were capable of moving single cells. Cargo unloading from bundles was achieved by incubation with Triton X-100. These data suggest that actin bundling may improve the ability of the myosin motor system for nanotransport applications.
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