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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Published on: May 16, 2025

Phenomena in dermatology.

Bhushan Madke1, Bhavana Doshi, Sushil Pande

  • 1Department of Dermatology, Seth GS Medical College and KEM Hospital, Parel, Mumbai-400 012, India.

Indian Journal of Dermatology, Venereology and Leprology
|April 22, 2011
PubMed
Summary
This summary is machine-generated.

Understanding skin manifestations of systemic diseases requires knowledge of pathophysiologic processes. This review categorizes key clinical, laboratory, and histopathologic phenomena in dermatology for easier physician comprehension.

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Area of Science:

  • Dermatology
  • Pathophysiology
  • Internal Medicine

Background:

  • Dermatoses often reflect underlying systemic diseases.
  • A strong grasp of skin manifestations is crucial for physicians.
  • Understanding pathophysiologic links aids diagnosis and management.

Purpose of the Study:

  • To provide a structured overview of key phenomena in systemic diseases affecting the skin.
  • To enhance physicians' theoretical knowledge of dermatologic manifestations.
  • To simplify the learning of complex pathophysiologic processes.

Main Methods:

  • Categorization of phenomena into clinical, laboratory, and histopathologic groups.
  • Discussion of specific examples within each category.
  • Focus on phenomena relevant to systemic diseases impacting the skin.

Main Results:

  • Phenomena are classified into clinical (Meyerson, Meirowsky, pathergy, Renbok), laboratory (LE cell, prozone), and histopathologic (Splendore-Hoeppli) categories.
  • Each category highlights important diagnostic and pathophysiologic indicators.
  • Provides a framework for understanding skin-systemic disease interactions.

Conclusions:

  • A systematic approach to understanding dermatoses is essential for physicians.
  • Knowledge of specific clinical, laboratory, and histopathologic findings aids in diagnosing systemic diseases.
  • This categorization facilitates a deeper understanding of the pathophysiology of skin involvement in systemic conditions.