Highlighting a histopathological dilemma: atypical dermatofibrosarcoma protuberans diagnosed with multimodal
Varun H1, Adarshlata Singh1, Ambika Kondalkar1
1Department of Dermatology, Venereology and Leprosy, Datta Meghe Institute of Higher Education and Research, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.
None:
An adult male agricultural worker presented with an asymptomatic, heterogeneously pigmented, indurated nodule featuring multiple protuberances on the left pelvic skin. Cross-polarized dermoscopy revealed pink structureless areas and a hyperpigmented reticular network; yellow light dermoscopy accentuated the pigmentary network and entangling vasculature. Ultraviolet-induced fluorescence dermoscopy demonstrated blue-white autofluorescence of surface keratin and milky-white fluorescence of the collagenous/myxoid stroma. Histopathology showed a monomorphic spindle-cell infiltrate without atypia; immunohistochemistry (IHC) confirmed a CD34-positive, S100-negative spindle-cell neoplasm consistent with a myxoid variant of dermatofibrosarcoma protuberans. This case highlights the diagnostic utility of multimodal dermoscopy integrated with histopathology and supportive IHC in precisely evaluating atypical cutaneous tumours.
Related Concept Videos
01:30Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:11Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...