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Updated: Feb 10, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat VNTR - Fragment Length Analysis FLA
Published on: July 15, 2011
Nodular and abscessed pinna in lepromatous leprosy with Type 2 lepra reaction
Naga Nitya Vangala1, Manisha Gedam2, Adarshlata Singh1
1Department of Dermatology, Venereology & Leprosy, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.
Abstract:
Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae, with a predilection for cooler areas of the body such as the external ear. We report a man in his late thirties with lepromatous leprosy, presenting with an eight-month history of facial and auricular nodules that progressed to erythema, ulceration, and sensory impairment. The clinical examination revealed infiltrated, nodular pinnae, a cheek ulcer, and bilateral ulnar neuritis. Slit-skin smear revealed abundant acid-fast bacilli (BI 6 +), and histopathology confirmed the multibacillary spectrum. The acute erythema, painful tender nodules, and neuritis were consistent with a Type 2 lepra reaction (erythema nodosum leprosum, ENL). The patient was treated with the WHO-recommended multidrug therapy for multibacillary leprosy (MB-MDT) and oral corticosteroids, showing progressive clinical improvement. This case underscores that external ear involvement, though a recognized feature of multibacillary leprosy, may be easily overlooked, particularly when complicated by lepra reactions. Timely recognition and prompt management of lepra reactions are essential to prevent irreversible neuropathy and disfigurement.
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