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Microbial Biosensors

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Updated: Jun 2, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Recent progress in SERS biosensing.

Kyle C Bantz¹, Audrey F Meyer, Nathan J Wittenberg

¹Department of Chemistry, University of Minnesota, Twin Cities, USA.

Physical Chemistry Chemical Physics : PCCP

|April 22, 2011

Summary

This summary is machine-generated.

Surface-Enhanced Raman Scattering (SERS) offers advanced biosensing for detecting various biological molecules. Recent progress in SERS substrates and techniques shows great potential for widespread adoption in biological sensing applications.

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Area of Science:

Analytical Chemistry
Biotechnology
Spectroscopy

Background:

Surface-Enhanced Raman Scattering (SERS) is a powerful technique for detecting analytes at low concentrations.
Biosensing applications require sensitive and specific detection methods for biological molecules.
Recent advancements have expanded the capabilities of SERS for complex biological samples.

Purpose of the Study:

To provide an overview of recent developments in SERS for biosensing.
To focus on SERS applications for detecting biological analytes over the last decade.
To discuss advancements in SERS substrate technology and methodologies.

Main Methods:

Review of SERS literature published in the last 10 years.
Analysis of intrinsic and extrinsic SERS biosensing schemes.
Discussion of SERS substrate technologies, surface chemistry, and sample preparation.

Main Results:

SERS has been successfully applied to detect small molecules, nucleic acids, lipids, peptides, and proteins.
In vivo and cellular sensing using SERS have been demonstrated.
Advancements in tip-enhanced Raman spectroscopy (TERS) are also discussed.

Conclusions:

SERS biosensing has shown significant progress and versatility.
Current SERS technologies and methodologies are promising for broader applications.
Widespread adoption of SERS biosensing is anticipated in the near future.