Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Infants and Children

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

One-Compartment Model: IV Infusion

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

Two-Compartment Open Model: IV Infusion

Two-Compartment Open Model: IV Infusion

A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Experimental-design Specific Changes in Spontaneous EEG and During Intermittent Photic Stimulation by High Definition Transcranial Direct Current Stimulation.

Neuroscience·2019

Same author

[The clinical and expert evaluation of the unfavourable consequences of the provision of the dental implantation treatment].

Sudebno-meditsinskaia ekspertiza·2017

Same author

[About rare causes of the loss of hearing].

Vestnik otorinolaringologii·2015

Same author

[Effect of succinate-containing solution on the level of metabolism during perioperative period in children].

Anesteziologiia i reanimatologiia·2015

Same author

[Observation of tetanus in a teenager].

Klinichna khirurhiia·2014

Same author

[Haemodynamics during kidney transplantation and general anaesthesia in combination with epidural block and without it in pediatric patients].

Anesteziologiia i reanimatologiia·2013

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery

Published on: September 30, 2021

[Postoperative infusion therapy in children].

V V Lazarev, L E Tsypin, G V Kornienko

Anesteziologiia I Reanimatologiia

|April 23, 2011

Summary

This study compared Voluven 6% and HAES-steril 10% in pediatric patients, finding both effectively manage hemodynamics during surgery. Voluven 6% increased limb fluid, while HAES-steril 10% shifted fluid to the torso.

Area of Science:

Pediatric Anesthesiology
Fluid Management
Hemodynamics

Background:

Intraoperative fluid management is crucial in pediatric surgery.
Colloids are frequently used to maintain hemodynamic stability.
Understanding the impact of different colloids on fluid balance is essential.

Purpose of the Study:

To compare the effects of Voluven 6% and HAES-steril 10% on hemodynamics and body water distribution in children undergoing surgery.
To evaluate the efficacy of these colloids in neutralizing anesthetic-induced hemodynamic changes and intraoperative fluid loss.

Main Methods:

A study involving 40 pediatric patients (3 months to 17 years) divided into two groups.
Administration of Voluven 6% (5 ml/kg/hour) for blood loss up to 15% of total circulating blood volume (TCBV).

More Related Videos

Guidelines for Elective Pediatric Fiberoptic Intubation

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Related Experiment Videos

Last Updated: Jun 2, 2026

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery

Published on: September 30, 2021

Guidelines for Elective Pediatric Fiberoptic Intubation

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Administration of HAES-steril 10% (4 ml/kg/hour) for blood loss up to 25% of TCBV.

Main Results:

Both Voluven 6% and HAES-steril 10% effectively neutralized hemodynamic changes and compensated for fluid loss.
Voluven 6% administration resulted in a significant decrease in lower limb impedance, indicating increased limb fluid.
HAES-steril 10% administration led to significant fluid redistribution, with a predominant increase in torso water.

Conclusions:

Colloid infusion at a 1:3 ratio with crystalloids effectively manages hemodynamics and fluid balance in pediatric surgery.
Voluven 6% and HAES-steril 10% have distinct effects on body water distribution.
These findings aid in optimizing fluid management strategies in pediatric surgical patients.