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Updated: Jun 2, 2026

High Resolution Physical Characterization of Single Metallic Nanoparticles
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Published on: June 28, 2019

Voltage-controlled metal binding on polyelectrolyte-functionalized nanopores.

Paolo Actis1, Boaz Vilozny, R Adam Seger

  • 1Department of Biomolecular Engineering, University of California Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|April 23, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a novel nanopore sensor functionalized with polyelectrolytes that can detect metal ions. The sensor provides a real-time, concentration-dependent electrical signal without requiring molecular labeling.

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Published on: October 26, 2016

Area of Science:

  • Nanotechnology
  • Electrochemistry
  • Analytical Chemistry

Background:

  • Current nanopore research primarily focuses on molecule translocation and associated forces.
  • Molecular gating, a phenomenon where analytes interact with nanopore surface receptors, offers an alternative detection mechanism.

Purpose of the Study:

  • To develop a solid-state nanopore sensor capable of reversibly binding and detecting metal ions.
  • To establish a real-time, label-free method for monitoring analyte binding and studying binding thermodynamics.

Main Methods:

  • Functionalization of solid-state nanopores with polyelectrolytes via electrostatic interactions.
  • Monitoring changes in ion current through the nanopore in response to metal ion binding.
  • Utilizing applied voltage to tune the sensor's binding properties.

Main Results:

  • Demonstrated reversible binding of metal ions to the functionalized nanopore.
  • Observed a real-time, concentration-dependent electrical signal correlated with metal ion binding.
  • Showcased the ability to modulate binding affinity using applied voltage.

Conclusions:

  • The developed polyelectrolyte-functionalized nanopore serves as a sensitive and selective sensor for metal ions.
  • This label-free, electrical detection method offers a versatile platform for studying binding thermodynamics and has broad applications.