Related Experiment Video

Updated: Jun 2, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Analysis of cancer signaling networks by systems biology to develop therapies

Rexxi D Prasasya1, Dan Tian, Pamela K Kreeger

  • 1Department of Biomedical Engineering, University of Wisconsin-Madison, United States.

Seminars in Cancer Biology
|April 23, 2011
PubMed

Insights

Systems biology offers a new approach to understanding complex cancer heterogeneity. Analyzing multiple pathways and their interactions reveals therapeutic targets and predicts drug responses, revolutionizing cancer treatment.

Area of Science:

  • Oncology
  • Systems Biology
  • Bioinformatics

Background:

  • Cancer is a complex and heterogeneous disease, making it difficult to find single-target therapies.
  • Traditional approaches struggle with tumor variability and individual patient differences.

Purpose of the Study:

  • To review how systems biology can analyze high-throughput data for cancer research.
  • To explore the application of network-level analysis in cancer therapy.

Main Methods:

  • Translating high-throughput data into cellular signaling networks.
  • Computational analysis of information flow within these networks.
  • Reviewing studies that use network-level analysis for therapeutic insights.

Main Results:

  • Systems biology enables a comprehensive analysis of cancer pathways and interactions.
  • Network analysis can identify novel therapeutic targets.
  • Predicting tumor sensitivity to drugs and developing combination therapies are key applications.

Conclusions:

  • Systems biology provides a powerful framework for understanding and treating cancer.
  • Network-level analysis holds significant potential to revolutionize cancer therapy by targeting multiple pathways.

More Related Videos

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...