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Related Concept Videos

Mass Spectrometry: Alcohol Fragmentation01:03

Mass Spectrometry: Alcohol Fragmentation

Alcohols (R-OH) ionize to lose one non-bonded electron from the oxygen atom, forming molecular ions. Due to their tendency to fragment rapidly, the intensity of the molecular ion peak in the mass spectrum is weak or sometimes absent. The fragmentation patterns for alcohols occur in two ways, i.e. ⍺-cleavage and dehydration. During ⍺-cleavage, the bond at the ⍺-position adjacent to the hydroxyl group cleaves to give a resonance-stabilized cation and a radical. However, intramolecular dehydration...

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Expression Profiling in Alcoholism Research.

Susan E Bergeson1, Ari E Berman, Peter R Dodd

  • 1The Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, The University of Texas at Austin, Austin, Texas, USA (SEB, AEB, KHL), SMMS, University of Queensland, Brisbane, Australia (PRD, JML), Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA (HJE), Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA (RJH), Laboratory of Clinical and Translational Science, NIAAA, NIH, Bethesda and Div of Psychiatry, NEUROTEC, Karolinska Institute, Stockholm, Sweden (WS).

Alcoholism, Clinical and Experimental Research
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

This research explores gene expression and functional genomics in alcoholism. Findings highlight potential targets for treating alcohol use disorder by analyzing brain gene and protein expression.

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Area of Science:

  • Biomedical research on alcohol
  • Neuroscience
  • Genomics

Background:

  • Alcohol use disorder (AUD) is a complex condition with significant public health implications.
  • Understanding the genetic and molecular underpinnings of AUD is crucial for developing effective treatments.
  • Previous research has identified genetic factors influencing alcohol preference and response.

Purpose of the Study:

  • To present findings from a symposium on the biomedical research on alcoholism.
  • To explore gene expression patterns in alcohol-preferring and non-preferring rats.
  • To identify potential therapeutic targets for alcoholism using functional genomics and molecular analyses.

Main Methods:

  • Gene expression analysis in rat models of alcohol preference.
  • Functional genomics approaches to identify candidate treatment targets.
  • Microarray analysis to study alcohol's effects on brain gene expression (acute and chronic).
  • Integration of quantitative trait loci (QTL) and gene expression data.
  • Microarray and proteomic analysis of the human alcoholic brain.

Main Results:

  • Differences in gene expression were observed between alcohol-preferring and non-preferring rats.
  • Functional genomics provided insights into potential molecular targets for alcoholism treatment.
  • Microarray analysis revealed significant changes in brain gene expression following acute and chronic alcohol exposure.
  • Integration of QTL and gene expression data offered a comprehensive view of genetic influences.
  • Proteomic and gene expression data from the human alcoholic brain provided translational insights.

Conclusions:

  • Gene expression patterns in the brain are associated with alcohol preference and response.
  • Functional genomics and molecular analyses offer promising avenues for developing novel alcoholism treatments.
  • Further research integrating genomic and proteomic data is essential for a deeper understanding of AUD pathophysiology.