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Related Experiment Video

Updated: Jun 2, 2026

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Published on: August 26, 2014

Colonoscopic injection for murine solid cecal cancer model.

Joshua R Karas¹, Rahila Essani, Christopher Haughn

¹Division of Colon & Rectal Surgery, State University of New York, Academic Office, HSC, T18-046B, Stony Brook, NY 11794-8191, USA.

Surgical Endoscopy

|April 23, 2011

Summary

This summary is machine-generated.

This study developed a reliable rat colon cancer model by injecting a cancer cell line into the cecal wall, achieving a high success rate for solid tumor formation in 79% of rats.

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Last Updated: Jun 2, 2026

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Published on: August 26, 2014

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Published on: December 4, 2007

Subcutaneous Injection of Human Colorectal Cancer Cells in Athymic Nude Mice to Evaluate Antitumor Efficacy

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Published on: July 8, 2025

Area of Science:

Oncology
Animal Models
Gastroenterology

Background:

Current animal models for colon cancer lack sufficient validity.
Developing reliable models is crucial for advancing colon cancer research.

Purpose of the Study:

To evaluate the efficacy of colonoscopic injection of a murine colon cancer cell line into the cecal wall of immunocompetent rats.
To establish a reproducible in vivo model for studying colon cancer.

Main Methods:

107 male rats underwent colonoscopy with submucosal injection of a colon tumor cell suspension into the cecal wall.
Tumor growth was assessed via necropsy at 4 weeks post-injection.
Histological analysis confirmed tumor type and size.

Main Results:

A single solid cecal cancer was successfully induced in 91.5% of rats.
Histology confirmed adenocarcinoma with a median tumor size of 4 mm.
Complications were minimal, occurring in 3.8% of rats.

Conclusions:

Colonoscopic injection of a rat colon cancer cell line is an effective method for developing solid cecal tumors in immunocompetent rats.
This technique provides a valid and reproducible animal model for colon cancer research.
The model demonstrated a high success rate (79%) in generating tumors without significant metastasis or carcinomatosis.